[1] [4] It works by mimicking the action of the naturally occurring hormone GLP-1, which stimulates insulin secretion in response to food intake, suppresses glucagon release, slows gastric emptying, and reduces appetite through central nervous system pathways
Patients and caregivers need to monitor for worsening depression or changes in behavior, as this could be a sign of suicidal thoughts and seek immediate assistance if they occur
doi:10.1007/s00592-011-0359-9 [PMID: 22160246] Faurschou A, et al
DPP-4 Inhibitors and BP Regulation: Potential Mechanisms Primary hypertension is a cardiovascular syndrome characterized by elevated BP, and represents the leading cause of cardiovascular disease and stroke and the primary cause of death and disease burden worldwide ( Immunological Mechanisms of DPP-4i Upon Hypertension Many chronic diseases are closely related to non-specific inflammatory processes, such as insulin resistance, metabolic syndrome, T2DM, and coronary heart disease, which are associated with increased infiltration and cell proliferation of immune cells and the elevated release of inflammatory mediators
Some of the diabetes medications that may interact with semaglutide include: Insulin Dulaglutide Exenatide Liraglutide Byetta Trulicity Victoza Other Interactions In addition to diabetes medications, semaglutide can interact with a wide range of other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products
doi: 10.1038/s41591-025-04102-x 17